How to Achieve Different Release Profiles and Select Excipients for Formulation Development of Modified Release Oral Solid Dosage Forms

In pharmaceutical manufacturing, modified release (such as extended or controlled release) formulation is notoriously challenging. Achieving an effective formulation requires a holistic, well-researched view of:

  • API characteristics
  • Desired pharmacokinetic (PK) profile
  • Appropriate excipients
  • Dosage form selection
  • Manufacturing techniques

In this white paper, Recro expert Myke Scoggins explains how diverse elements from particle size distribution to process optimization factor into achieving a successful modified release oral solid dosage formulation.